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Article

Homozygotes and heterozygotes for ciliary neurotrophic factor null alleles do not show earlier onset of Huntington's disease.

Neurology - 1 Sept 1997

Rubinsztein D C, Leggo J, Chiano M, Korn S, Dodge A, Norbury G, Rosser E, Craufurd D

Abstract excerpt

The CAG repeat number on Huntington's disease (HD) chromosomes accounts for about 60% of the variance in the age at onset of HD. However, distinct familial factors may also influence the age at onset. HD is associated with loss of medium-sized GABA-ergic striatal output neurons. Intracerebral adm...

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Source

Identifiers

PMID: 9305364
DOI: 10.1212/wnl.49.3.890

Genes

CNTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9305364-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Homozygotes and heterozygotes for ciliary neurotrophic factor null alleles do not show earlier onset of Huntington's disease.PMID 9305364Read ↗

No evidence of association between BDNF gene variants and age-at-onset of Huntington's disease.Semantic proximity Read ↗

Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease.Semantic proximity Read ↗

A null mutation in the human CNTF gene is not causally related to neurological diseases.Semantic proximity Read ↗

The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease.Semantic proximity Read ↗

Ciliary neurotrophic factor null allele frequencies in schizophrenia, affective disorders, and Alzheimer's disease.Semantic proximity Read ↗

Ciliary neurotrophic factor null alleles are not a risk factor for Charcot-Marie-Tooth disease, hereditary neuropathy with pressure palsies and amyotrophic lateral sclerosis.Semantic proximity Read ↗

[Deficiency of human ciliary neurotropic factor (CNTF) is not causally related to amyotrophic lateral sclerosis (ALS)].Semantic proximity Read ↗

Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Brain-derived neurotrophic factor in cerebrospinal fluid and plasma is not a biomarker for Huntington’s diseaseSemantic proximity Read ↗

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