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Article

Decrease in the ciliary neurotrophic factor of the spinal cord in amyotrophic lateral sclerosis.

European neurology - 1 Jan 1999

Ono S, Imai T, Igarashi A, Shimizu N, Nakagawa H, Hu J

Abstract excerpt

Ciliary neurotrophic factor (CNTF), a potent survival factor in spinal motoneurons of embryonic chick and rat, is currently being investigated in humans as a treatment for amyotrophic lateral sclerosis (ALS). However, its physiological and pathological activities in ALS remain unclear. We measured CNTF contents in the cervical enlargement of the spinal cord from 9 ALS patients and 12 age-matched control subjects...

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Source

Identifiers

PMID: 10529543
DOI: 10.1159/000008092

Genes

CNTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 9 closest

Decrease in the ciliary neurotrophic factor of the spinal cord in amyotrophic lateral sclerosis.PMID 10529543Read ↗

[Deficiency of human ciliary neurotropic factor (CNTF) is not causally related to amyotrophic lateral sclerosis (ALS)].Semantic proximity Read ↗

Investigation of a null mutation of the CNTF gene in familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Ciliary neurotrophic factor (CNTF) genotypes: influence on choline acetyltransferase (ChAT) and acetylcholine esterase (AChE) activities and neurotrophin 3 (NT3) concentration in human post mortem brain tissue.Semantic proximity Read ↗

Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis.Semantic proximity Read ↗

A null mutation in the human CNTF gene is not causally related to neurological diseases.Semantic proximity Read ↗

Differentiation of cholinergic neurons and physiological role of ciliary neurotrophic factor (CNTF).Semantic proximity Read ↗

Association of a null mutation in the CNTF gene with early onset of multiple sclerosis.Semantic proximity Read ↗

Association between a null mutation in the human ciliary neurotrophic factor (CNTF) gene and increased incidence of psychiatric diseases?Semantic proximity Read ↗

Increased expression of connective tissue growth factor in amyotrophic lateral sclerosis human spinal cordSemantic proximity Read ↗

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