Article
Bone marrow transfer from wild-type mice reverts the beneficial effect of genetically mediated immune deficiency in myelin mutants.
Molecular and cellular neurosciences - 1 Jun 2001
Mäurer M, Schmid C D, Bootz F, Zielasek J, Toyka K V, Oehen S, Martini R
Abstract excerpt
Inherited demyelinating neuropathies are chronically disabling human disorders caused by various genetic defects, including deletions, single site mutations, and duplications in the respective myelin genes. We have shown in a mouse model of one distinct hereditary demyelinating neuropathy (heterozygous P0-deficiency, P0+-) that an additional null mutation in the recombination activating gene-1 (RAG-1--) leads to...
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