Article
The Caenorhabditis elegans spalt-like gene sem-4 restricts touch cell fate by repressing the selector Hox gene egl-5 and the effector gene mec-3.
Development (Cambridge, England) - 1 Aug 2003
Toker Anne S, Teng Yingqi, Ferreira Henrique B, Emmons Scott W, Chalfie Martin
Abstract excerpt
Members of the spalt (sal) gene family encode zinc-finger proteins that are putative tumor suppressors and regulate anteroposterior (AP) patterning, cellular identity, and, possibly, cell cycle progression. The mechanism through which sal genes carry out these functions is unclear. The Caenorhabditis elegans sal gene sem-4 controls the fate of several different cell types, including neurons, muscle and...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Lineage
- DNA-Binding Proteins
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Genes, Reporter
- Homeodomain Proteins
- Humans
- LIM-Homeodomain Proteins
- Mechanoreceptors
- Mechanotransduction, Cellular