Article
Evidence of increased visceral obesity and reduced physical fitness in healthy insulin-resistant first-degree relatives of type 2 diabetic patients.
European journal of endocrinology - 1 Feb 2004
Nyholm Birgit, Nielsen Michael F, Kristensen Kurt, Nielsen Søren, Østergård Torben, Pedersen Sten B, Christiansen Thomas, Richelsen Bjørn, Jensen Michael D, Schmitz Ole
Abstract excerpt
OBJECTIVE: First-degree relatives (FDR) of type 2 diabetic patients are often insulin resistant. Visceral obesity is closely linked to both insulin resistance and type 2 diabetes. We therefore hypothesized that the inheritance of an increased tendency to store fat in visceral fat depots may be a characteristic phenotypic feature in FDR contributing to their insulin resistance. DESIGN AND METHODS: We measured fat...
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