Article
The influence of 3TC resistance mutation M184I on the fidelity and error specificity of human immunodeficiency virus type 1 reverse transcriptase.
Nucleic acids research - 15 Jun 1998
Rezende L F, Drosopoulos W C, Prasad V R
Abstract excerpt
A common target for therapies against human immuno-deficiency virus type 1 (HIV-1) is the viral reverse transcriptase (RT). Treatment with the widely used nucleoside analog (-)-2', 3'-deoxy-3'-thiacytidine (3TC) leads to the development of resistance-conferring mutations at residue M184 within th...
Topics
- Bacteriophage M13
- Base Sequence
- DNA Mutational Analysis
- DNA, Viral
- Drug Resistance, Microbial
- Frameshift Mutation
- Genes, Reporter
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Lac Operon
- Lamivudine
- Methionine
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Point Mutation
- Reverse Transcriptase Inhibitors