Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of ISC1 by site-directed mutagenesis.

Biochemistry - 1 Jul 2003

Okamoto Yasuo, Vaena de Avalos Silvia, Hannun Yusuf A

Abstract excerpt

We previously reported that the yeast Saccharomyces cerevisiae ISC1 gene (Yer019w), which has homology to the bacterial sphingomyelinase gene, encodes inositol phosphosphingolipids-phospholipase C, Isc1p [Sawai, H., Okamoto, Y., Luberto, C., Mao, C., Bielawska, A., Domae, M., and Hannun, Y. A. (2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to Conserved Sequence
Share to Fungal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Phospholipases

Share to Saccharomyces cerevisiae Proteins

Share to Structure-Activity Relationship

Share to Type C Phospholipases

Source

Identifiers

PMID: 12820895
DOI: 10.1021/bi0341354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12820895-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of ISC1 by site-directed mutagenesis.PMID 12820895Read ↗

Role for Sit4p‐dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p‐deficient cellsSemantic proximity Read ↗

Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference.Semantic proximity Read ↗

Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro.Semantic proximity Read ↗

Carboxyl-terminal disulfide bond of acid sphingomyelinase is critical for its secretion and enzymatic function.Semantic proximity Read ↗

Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae.Semantic proximity Read ↗

Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis.Semantic proximity Read ↗

Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy.Semantic proximity Read ↗

Isolation and characterization of temperature-sensitive plc1 mutants of the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Suppressors of the Ca(2+)-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity.Semantic proximity Read ↗

Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase.Semantic proximity Read ↗

Saccharomyces cerevisiae PKC1 encodes a protein kinase C (PKC) homolog with a substrate specificity similar to that of mammalian PKC.Semantic proximity Read ↗

Novel Tumor Necrosis Factor-responsive Mammalian Neutral Sphingomyelinase-3 Is a C-tail-anchored ProteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.