Article
Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells.
American journal of physiology. Lung cellular and molecular physiology - 1 Apr 2004
You Yingjian, Huang Tao, Richer Edward J, Schmidt Jens-Erik Harboe, Zabner Joseph, Borok Zea, Brody Steven L
Abstract excerpt
Factors required for commitment of an undifferentiated airway epithelial cell to a ciliated cell are unknown. Cell ultrastructure analysis indicates ciliated cell commitment activates a multistage program involving synthesis of cilia precursor proteins and assembly of macromolecular complexes. Foxj1 is an f-box transcription factor expressed in ciliated cells and shown to be required for cilia formation by gene...
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