Article
Identification of the retinoic acid and thyroid hormone receptor-responsive element in the human K14 keratin gene.
The Journal of investigative dermatology - 1 Dec 1992
Tomic-Canic M, Sunjevaric I, Freedberg I M, Blumenberg M
Abstract excerpt
The promoter of human K14 keratin gene, specific for the basal layer of stratified epithelia, is regulated by nuclear receptors for retinoic acid and thyroid hormone. However, the DNA sequences responsible for this regulation have not yet been identified. To identify the retinoic acid-responsive...
Topics
- Base Sequence
- Carrier Proteins
- Gene Deletion
- Gene Expression Regulation
- Humans
- Keratins
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Promoter Regions, Genetic
- Receptors, Retinoic Acid
- Receptors, Thyroid Hormone