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Article

Linked linear amplification for simultaneous analysis of the two most common hemochromatosis mutations.

Clinical chemistry - 1 Jul 2003

Killeen Anthony A, Breneman John W, Carillo Arlene R, Ugozzoli Luis A, Lowery Jimmie D, Liu Jason, Hixson Craig S

Abstract excerpt

BACKGROUND: Two mutations in HFE, G845A (amino acid substitution C282Y) and C187G (H63D), are associated with hereditary hemochromatosis. We developed and validated a novel method, linked linear amplification (LLA), for detection of these two mutations. METHODS: Two segments of HFE were amplified by a multiplex LLA reaction that generated biotinylated LLA products. Aliquots of the multiplex LLA reaction were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class I

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Share to Polymorphism, Restriction Fragment Length

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Source

Identifiers

PMID: 12816900
DOI: 10.1373/49.7.1050

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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