Article
High-performance liquid chromatography multiplex detection of two single nucleotide mutations associated with hereditary hemochromatosis.
Journal of chromatography. B, Biomedical sciences and applications - 15 Apr 2001
Liang Q, Davis P A, Thompson B H, Simpson J T
Abstract excerpt
High-performance liquid chromatography (HPLC) has been applied to the multiplex detection of the two single nucleotide mutations commonly found in hereditary hemochromatosis (HH). HH is associated with a major G to A transition at position 845 (mutation Cys282Tyr) and a minor C to G transition at position 187 (mutation His63Asp) in the cDNA of the HFE gene. Two detection assays were developed based on HPLC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.