Article
Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT-1 in striatum of asymptomatic volunteers and patients with Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2003
Lynch David R, Mozley P David, Sokol Set, Maas Nicole M C, Balcer Laura J, Siderowf Andrew D
Abstract excerpt
SPECT scanning using (99)Tc-TRODAT-1, a ligand that binds to dopamine transporters, may be useful for detection of early Parkinson's disease (PD), diagnosis of presymptomatic individuals, and monitoring disease progression. Understanding whether genetic factors contribute to inter-individual variability is crucial for interpreting imaging results in the context of disease pathophysiology. We tested whether...
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