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Article

The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis.

Cancer research - 15 Jun 2003

Xue Chengsen, Plieth David, Venkov Christo, Xu Carol, Neilson Eric G

Abstract excerpt

When carcinoma cells metastasize, they change their phenotype to enhance motility. Cells making this switch selectively express S100A4, a p53-associated, calcium-binding protein known in the fibroblast literature as fibroblast-specific protein-1 (FSP1). FSP1 normally acts as a conversion signal for the local formation of tissue fibroblasts by epithelial-mesenchymal transition. We describe here a novel connection...

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PMID: 12810675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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