Article
Is there a role for genetic testing in patients with melanoma?
Current opinion in oncology - 1 Mar 2003
Kefford Richard F, Mann Graham J
Abstract excerpt
Autosomal dominant inheritance of mutations in the locus or the gene may confer a high risk of cutaneous melanoma development. The penetrance of mutations is influenced by UV exposure. Inherited variants in the melanocortin-1 receptor also confer increased risk of cutaneous melanoma. Features associated with increased genetic susceptibility to cutaneous melanoma include the presence of multiple affected...
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