Article
Application of denaturing gradient gel electrophoresis (DGGE) to screen for mutations of the human glucocorticoid receptor alpha gene (hGRalpha).
Clinical biochemistry - 1 Jun 2003
Tsolakidou Amalia F, Coulocheri Stavroula A, Sekeris Constantine E, Moutsatsou Paraskevi
Abstract excerpt
OBJECTIVES: In a previous publication, we had presented a sensitive method to detect mutations of the segment of the human glucocorticoid receptor alpha (hGRalpha) gene encoding the ligand binding domain (LBD) and part of the DNA binding domain (DBD) of hGRalpha, as several types of glucocorticoid resistance syndromes have been correlated with mutations in the respective nucleotide sequences. However, mutations...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.