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Article

Identification of a pathogenic epitope involved in initiation of Heymann nephritis.

1 Dec 1992

Abstract excerpt

Heymann nephritis is an experimental autoimmune disease model for human membranous nephropathy. We have recently identified a pathogenic epitope, clone 14 (C14), responsible for formation and deposition of glomerular immune complexes that is contained within the small subunit of the Heymann nephritis antigenic complex (HNAC). HNAC is a heterodimer composed of a large subunit designated gp330 and a smaller (44...

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PMID: 1280820
DOI: 10.1073/pnas.89.23.11179

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