Article
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.
American journal of human genetics - 1 Jul 2003
Lewis Cathryn M, Levinson Douglas F, Wise Lesley H, DeLisi Lynn E, Straub Richard E, Hovatta Iiris, Williams Nigel M, Schwab Sibylle G, Pulver Ann E, Faraone Stephen V, Brzustowicz Linda M, Kaufmann Charles A, Garver David L, Gurling Hugh M D, Lindholm Eva, Coon Hilary, Moises Hans W, Byerley William, Shaw Sarah H, Mesen Andrea, Sherrington Robin, O'Neill F Anthony, Walsh Dermot, Kendler Kenneth S, Ekelund Jesper, Paunio Tiina, Lönnqvist Jouko, Peltonen Leena, O'Donovan Michael C, Owen Michael J, Wildenauer Dieter B, Maier Wolfgang, Nestadt Gerald, Blouin Jean-Louis, Antonarakis Stylianos E, Mowry Bryan J, Silverman Jeremy M, Crowe Raymond R, Cloninger C Robert, Tsuang Ming T, Malaspina Dolores, Harkavy-Friedman Jill M, Svrakic Dragan M, Bassett Anne S, Holcomb Jennifer, Kalsi Gursharan, McQuillin Andrew, Brynjolfson Jon, Sigmundsson Thordur, Petursson Hannes, Jazin Elena, Zoëga Tomas, Helgason Tomas
Abstract excerpt
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins...
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