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Article

Microenvironment and phenotypic stability specify tissue formation by human articular cartilage-derived cells in vivo.

Experimental cell research - 1 Jul 2003

Dell'Accio Francesco, De Bari Cosimo, Luyten Frank P

Abstract excerpt

During in vitro expansion, adult human articular cartilage-derived cells (HACDC) lose their phenotypic stability and capacity to form cartilage in vivo after 4-6 population doublings (PD). Nevertheless, HACDC can be efficiently expanded for up to 20 PD. Here we show that HACDC can generate cartil...

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Identifiers

PMID: 12799178
DOI: 10.1016/s0014-4827(03)00036-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12799178-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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