Article
An aminoacylation ribozyme evolved from a natural tRNA-sensing T-box riboswitch.
Nature chemical biology - 1 Jun 2020
Ishida Satoshi, Terasaka Naohiro, Katoh Takayuki, Suga Hiroaki
Abstract excerpt
When the primitive translation system first emerged in the hypothetical RNA world, ribozymes could have been responsible for aminoacylation. Given that naturally occurring T-box riboswitches selectively sense the aminoacylation status of cognate tRNAs, we introduced a domain of random sequence into a T-box-tRNA conjugate and isolated ribozymes that were self-aminoacylating on the 3'-terminal hydroxyl group. One...
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