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Article

A novel mechanism of myocyte degeneration involving the Ca2+-permeable growth factor–regulated channel

9 Jun 2003

Abstract excerpt

Disruption of the dystrophin-glycoprotein complex caused by genetic defects of dystrophin or sarcoglycans results in muscular dystrophy and/or cardiomyopathy in humans and animal models. However, the key early molecular events leading to myocyte degeneration remain elusive. Here, we observed that the growth factor-regulated channel (GRC), which belongs to the transient receptor potential channel family, is...

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PMID: 12796481
DOI: 10.1083/jcb.200301101

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