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Article

Dilated cardiomyopathy mutations in δ-sarcoglycan exert a dominant-negative effect on cardiac myocyte mechanical stability.

American journal of physiology. Heart and circulatory physiology - 1 May 2016

Campbell Matthew D, Witcher Marc, Gopal Anoop, Michele Daniel E

Abstract excerpt

Delta-sarcoglycan is a component of the sarcoglycan subcomplex within the dystrophin-glycoprotein complex located at the plasma membrane of muscle cells. While recessive mutations in δ-sarcoglycan cause limb girdle muscular dystrophy 2F, dominant mutations in δ-sarcoglycan have been linked to inherited dilated cardiomyopathy (DCM). The purpose of this study was to investigate functional cellular defects present...

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Share to Cardiomyopathy, Dilated
Share to Cell Membrane Permeability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylation

Share to Mechanotransduction, Cellular

Share to Myocardial Contraction

Share to Myocytes, Cardiac

Share to Sarcoglycans

Share to Stress, Mechanical

Source

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Identifiers

PMID: 26968544
DOI: 10.1152/ajpheart.00521.2015
PMCID: PMC4867387

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