Article
Molecular pathophysiology of myofiber injury in deficiencies of the dystrophin-glycoprotein complex.
American journal of physical medicine & rehabilitation - 1 Nov 2002
Petrof Basil J
Abstract excerpt
Duchenne muscular dystrophy is caused by mutations in the gene encoding dystrophin, a 427 kd protein normally found at the cytoplasmic face of the sarcolemma. In normal muscle, dystrophin is associated with a multimolecular glycoprotein complex. Primary mutations in the genes encoding members of this glycoprotein complex are also associated with muscular dystrophy. The dystrophin-glycoprotein complex provides a...
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