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Article

Requirement of transcription factor NFAT in developing atrial myocardium.

The Journal of cell biology - 9 Jun 2003

Schubert William, Yang Xiao Yong, Yang Teddy T C, Factor Stephen M, Lisanti Michael P, Molkentin Jeffery D, Rincon Mercedes, Chow Chi-Wing

Abstract excerpt

Nuclear factor of activated T cell (NFAT) is a ubiquitous regulator involved in multiple biological processes. Here, we demonstrate that NFAT is temporally required in the developing atrial myocardium between embryonic day 14 and P0 (birth). Inhibition of NFAT activity by conditional expression of dominant-negative NFAT causes thinning of the atrial myocardium. The thin myocardium exhibits severe sarcomere...

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Identifiers

PMID: 12796475
DOI: 10.1083/jcb.200301058
PMCID: PMC2172977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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