Localization of Phospho-β-dystroglycan (pY892) to an Intracellular Vesicular Compartment in Cultured Cells and Skeletal Muscle Fibers in Vivo

Abstract excerpt

beta-Dystroglycan is a ubiquitously expressed integral membrane protein that undergoes tyrosine phosphorylation in an adhesion-dependent manner. Tyrosine 892 is now thought to be the principal site for recognition by the c-Src tyrosine kinase; however, little is known about the regulation of this phosphorylation event in vivo. Here, we generated a novel monoclonal antibody probe that recognizes only tyrosine 892...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Caveolin-1 and cellular processes
• Share to Erythrocyte Function and Pathophysiology
• Share to Signaling Pathways in Disease