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Article

Myelin protein zero: mutations in the cytoplasmic domain interfere with its cellular trafficking.

Journal of neuroscience research - 1 May 2006

Konde Viren, Eichberg Joseph

Abstract excerpt

The cytoplasmic domain of myelin protein zero (MPZ), the principal protein of peripheral myelin, undergoes phosphorylation on several serine residues and a tyrosine group that is maximal during peak nerve myelination. Mutations that could affect MPZ phosphorylation cause the inherited neuropathy, Charcot-Marie-Tooth disease Type 1B. To investigate a possible role for phosphorylation in regulation of MPZ...

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Identifiers

PMID: 16493674
DOI: 10.1002/jnr.20793

Genes

MPZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Myelin protein zero: mutations in the cytoplasmic domain interfere with its cellular trafficking.PMID 16493674Read ↗

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Overloaded endoplasmic reticulum-Golgi compartments, a possible pathomechanism of peripheral neuropathies caused by mutations of the peripheral myelin protein PMP22.Semantic proximity Read ↗

Myelin P0: new knowledge and new roles.Semantic proximity Read ↗

Conservation of topology, but not conformation, of the proteolipid proteins of the myelin sheath.Semantic proximity Read ↗

In silico and in vitro effects of the I30T mutation on myelin protein zero instability in the cell membrane.Semantic proximity Read ↗

Phenotypic differences between peripheral myelin protein-22 (PMP22) and myelin protein zero (P0) mutations associated with Charcot-Marie-Tooth-related diseases.Semantic proximity Read ↗

The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination.Semantic proximity Read ↗

How Does Protein Zero Assemble Compact Myelin?Semantic proximity Read ↗

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