Synthetic gene libraries: in search of the optimal diversity.

doi:10.1016/S0167-7799(03)00089-1

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Article

Synthetic gene libraries: in search of the optimal diversity.

Trends in biotechnology - 1 Jun 2003

Ostermeier Marc

Abstract excerpt

Directed evolution has proven to be an effective method for evolving proteins with desired properties. A key step is the creation of suitably diverse gene libraries. Two new methods for creating such libraries make sole use of synthesized oligonucleotides and allow researchers to tailor the diversity of a library with greater precision and create libraries with greater diversity than was previously possible. Such...

Topics

Cloning, Molecular
Directed Molecular Evolution
Epidermal Growth Factor
Gene Library
Genes, Synthetic
Genetic Engineering
Genetic Variation
Peptide Library
Protein Engineering
Proteins
Recombination, Genetic
Subtilisin

Source

Open in PubMed

Identifiers

PMID: 12788541
DOI: 10.1016/S0167-7799(03)00089-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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