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Lack of association between pro-inflammatory genotypes of the interleukin-1 (IL-1B -31 C/+ and IL-1RN 2/2) and gastric cancer/duodenal ulcer in Korean population.

Cytokine - 21 Feb 2003

Lee Seong-Gene, Kim Byungsik, Choi Wonyong, Lee Inchul, Choi Jaewon, Song Kyuyoung

Abstract excerpt

IL-1beta is a pro-inflammatory cytokine with multiple biological effects and is a potent inhibitor of gastric acid secretion, and IL-1RN has been shown to be associated with enhanced IL-1beta production in vitro. Recently, it was reported that the pro-inflammatory genotypes, IL-1B -31 C/+ and IL-1RN *2/*2, were associated with an increased risk of gastric cancer in a Caucasian population. We tested the...

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PMID: 12788304
DOI: 10.1016/s1043-4666(03)00032-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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