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Article

Nitric oxide formation by Escherichia coli. Dependence on nitrite reductase, the NO-sensing regulator Fnr, and flavohemoglobin Hmp.

The Journal of biological chemistry - 22 Aug 2003

Corker Hazel, Poole Robert K

Abstract excerpt

Nitric oxide (NO) is a key signaling and defense molecule in biological systems. The bactericidal effects of NO produced, for example, by macrophages are resisted by various bacterial NO-detoxifying enzymes, the best understood being the flavohemoglobins exemplified by Escherichia coli Hmp. However, many bacteria, including E. coli, are reported to produce NO by processes that are independent of denitrification...

Topics

Dihydropteridine Reductase
Escherichia coli
Escherichia coli Proteins
Hemeproteins
Iron-Sulfur Proteins
Mutation
NADH, NADPH Oxidoreductases
Nitric Oxide
Nitrite Reductases
Sensitivity and Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12783887
DOI: 10.1074/jbc.M303282200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12783887-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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