Article
Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration.
The EMBO journal - 8 Aug 2007
Yoon Sang Sun, Karabulut Ahmet C, Lipscomb John D, Hennigan Robert F, Lymar Sergei V, Groce Stephanie L, Herr Andrew B, Howell Michael L, Kiley Patricia J, Schurr Michael J, Gaston Benjamin, Choi Kyoung-Hee, Schweizer Herbert P, Hassett Daniel J
Abstract excerpt
Protection from NO gas, a toxic byproduct of anaerobic respiration in Pseudomonas aeruginosa, is mediated by nitric oxide (NO) reductase (NOR), the norCB gene product. Nevertheless, a norCB mutant that accumulated approximately 13.6 microM NO paradoxically survived anaerobic growth. Transcription...
Topics
- Anaerobiosis
- Bacterial Proteins
- Cystic Fibrosis
- Electrophoresis, Gel, Two-Dimensional
- Mutation
- Nitric Oxide
- Pseudomonas aeruginosa
- Spectrum Analysis
- Transcription, Genetic