Article
[Study of angiogenesis in human colorectal carcinoma and its modulation by p53 and K-ras gene].
Zhonghua nei ke za zhi - 1 Feb 2003
Zhong Shi-shun, Zhang Zhen-shu, Li Shu-mei, Deng Hai-jun, Ma Qiang
Abstract excerpt
OBJECTIVE: To investigate the angiogenesis in human colorectal carcinoma and its modulation by p53 and K-ras gene. METHODS: The positive rate of p53 and K-ras gene mutation, the expression of vascular endothelial growth factor (VEGF) and microvessel density in 68 cancer tissue, peritumoral tissue samples and 20 normal controls were studied by PCR-SSCP and immunohistochemical methods. RESULTS: The positive rate of...
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