Article
Nuclear cysteine cathepsin variants in thyroid carcinoma cells.
Biological chemistry - 1 Aug 2010
Tedelind Sofia, Poliakova Kseniia, Valeta Amanda, Hunegnaw Ruth, Yemanaberhan Eyoel Lemma, Heldin Nils-Erik, Kurebayashi Junichi, Weber Ekkehard, Kopitar-Jerala Nataša, Turk Boris, Bogyo Matthew, Brix Klaudia
Abstract excerpt
The cysteine peptidase cathepsin B is important in thyroid physiology by being involved in thyroid prohormone processing initiated in the follicular lumen and completed in endo-lysosomal compartments. However, cathepsin B has also been localized to the extrafollicular space and is therefore suggested to promote invasiveness and metastasis in thyroid carcinomas through, e.g., ECM degradation. In this study,...
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