Article
Dismantling of cadherin-mediated cell-cell contacts modulates smooth muscle cell proliferation.
Circulation research - 27 Jun 2003
Uglow Elizabeth B, Slater Sadie, Sala-Newby Graciela B, Aguilera-Garcia Concepción M, Angelini Gianni D, Newby Andrew C, George Sarah J
Abstract excerpt
Proliferation of vascular smooth muscle cells (VSMCs) contributes to intimal thickening during atherosclerosis and restenosis. The cadherins are transmembrane proteins, which form cell-cell contacts and may regulate VSMC proliferation. In this study, N-cadherin protein concentration was significa...
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