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Article

In vivo evolution of tumour cells after the generation of double-strand DNA breaks.

British journal of cancer - 2 Jun 2003

Mekid H, Tounekti O, Spatz A, Cemazar M, El Kebir F Z, Mir L M

Abstract excerpt

In vitro, the ratio of single- to double-strand DNA breaks (DSB) and their absolute values determine the cell death pathway. The consequences of the generation of various numbers of DSB generated in vivo in tumour cells have been analysed in two different experimental tumour models. Synchronisation of DSB generation and control of their number have been achieved using different doses of bleomycin (BLM) and tumour...

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Source

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Identifiers

PMID: 12771993
DOI: 10.1038/sj.bjc.6600959
PMCID: PMC2377151

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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