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Article

Correlation between DNA double strand breaks and cell death in peripheral blood lymphocytes from breast cancer patients.

International journal of radiation biology - 1 Jan 2025

Solana-Peña Ángela, Pujol-Canadell Monica, López Juan-Sebastián, Macià Miquel, Martínez Pérez Evelyn, Linares Isabel, Stefanovic Milica, Pérez-Montero Héctor, González-Viguera Javier, Arangüena Peñacoba Marina, Ventura Montse, Guedea Ferran, Erill Nadina, González-Rumayor Víctor, Armengol Gemma, Barquinero Joan Francesc

Abstract excerpt

PURPOSE: Radiotherapy affects both cancer and healthy cells, potentially causing side effects. Factors like total dose administered or patient individual characteristics, such as genetic variability, influence radiotoxicity. Several biomarkers have been proposed to predict radiotoxicity, especially those based on apoptosis or DNA damage, like γ-H2AX, which correlates with DNA breaks. Our aim is to analyze how...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

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Source

Identifiers

PMID: 40892441
DOI: 10.1080/09553002.2025.2548465

Genes

H2AX
FAS
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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