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Article

Mutation of lysine 405 to serine in the parvovirus H-1 NS1 abolishes its functions for viral DNA replication, late promoter trans activation, and cytotoxicity.

Journal of virology - 1 Oct 1990

Li X, Rhode S L

Abstract excerpt

A consensus sequence in parvovirus nonstructural protein NS1 has been predicted to be an ATP-binding domain associated with an ATPase and a DNA helicase activity. To investigate the function of NS1 in viral gene expression, a site-directed mutagenesis converting NS1 lysine 405 to serine in parvovirus H-1 was carried out by the polymerase chain reaction. As shown previously, a parvovirus genome containing a...

Topics

Capsid
Cell Line
Cell Transformation, Viral
DNA Replication
DNA, Viral
Humans
Lysine
Mutation
Parvoviridae
Plasmids
Promoter Regions, Genetic
Serine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcriptional Activation

Transfection

Viral Core Proteins

Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 2144594
DOI: 10.1128/JVI.64.10.4654-4660.1990
PMCID: PMC247949

Genes

CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2144594-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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