Article
Transmembrane sema4E guides branchiomotor axons to their targets in zebrafish.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 May 2003
Xiao Tong, Shoji Wataru, Zhou Weibin, Su Fengyun, Kuwada John Y
Abstract excerpt
Class 4 semaphorins are a large class of transmembrane proteins that contain a sema domain and that are expressed in the CNS, but their in vivo neural function is unknown. In zebrafish, the epithelial cells that line the pharyngeal arches express Sema4E. Extension of branchiomotor axons along the mesenchymal cells bounded by these epithelial cells suggests that Sema4E may act as a repulsive guidance molecule to...
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