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Article

Plasmid stability during in vitro propagation of Borrelia burgdorferi assessed at a clonal level.

Infection and immunity - 1 Jun 2003

Grimm Dorothee, Elias Abdallah F, Tilly Kit, Rosa Patricia A

Abstract excerpt

Borrelia burgdorferi causes Lyme disease in humans. The genome of the sequenced type strain B31 MI consists of a linear chromosome, 12 linear plasmids, and 9 circular plasmids. Previous studies by other investigators indicated that some of these plasmids are essential for the survival of the spirochetes in vivo but not in vitro. We have studied plasmid stability during in vitro growth at 23 and 35 degrees C,...

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Identifiers

PMID: 12761092
DOI: 10.1128/IAI.71.6.3138-3145.2003
PMCID: PMC155697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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