Article
Current insights into familial spastic paraparesis: new advances in an old disease.
Functional neurology - 1 Jan 2000
Fortini Daniela, Cricchi Federica, Di Fabio Roberto, Damiano Maria, Comanducci Giovanna, Benedetti Laura, Valoppi Manuela, Grieco Gaetano S, D'Eugenio Ottavio, Celato Andrea, Santorelli Filippo, Casali Carlo, Amabile Giuseppe A, Pierelli Francesco
Abstract excerpt
Hereditary spastic paraparesis (HSP) comprises a clinically and genetically heterogeneous group of disorders characterized by progressive spasticity and hyperreflexia of the lower limbs. The past few years have witnessed an exponential increase in knowledge of this disease and we can now list 19 loci mapped on the human genome and eight genes cloned. However, this wider knowledge of the molecular basis of HSP has...
Topics
- Chromosome Aberrations
- Chromosome Disorders
- Chromosome Mapping
- Chromosomes, Human, X
- Genes, Dominant
- Genes, Recessive
- Genetic Predisposition to Disease
- Humans
- Sex Chromosome Aberrations
- Spastic Paraplegia, Hereditary