Article
Sensitivity of non-small-cell lung cancer cell lines established from patients treated with prolonged infusions of Paclitaxel.
Oncology - 1 Jan 2003
Fujishita Takashi, Loda Massimo, Turner Ross E, Gentler Marinshine, Kashii Tatsuhiko, Breathnach Oscar S, Johnson Bruce E
Abstract excerpt
OBJECTIVE: Regimens with prolonged infusions of taxanes have been developed for patients with cancer to overcome drug resistance. Our objective of the present study was to examine the impact of prolonged exposure on the cytotoxicity of taxanes against non-small-cell lung carcinoma (NSCLC) cell lines and the clinical response and outcome of the patients. METHODS: Five cell lines (NCI-H2882, -H2887, -H2973, -H3122,...
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