Article
Glucose 6-Phosphate Dehydrogenase Is Required for Salmonella typhimurium Virulence and Resistance to Reactive Oxygen and Nitrogen Intermediates
1 Jan 1999
Abstract excerpt
Salmonella typhimurium zwf mutants lacking glucose 6-phosphate dehydrogenase (G6PD) activity have increased susceptibility to reactive oxygen and nitrogen intermediates as well as attenuated virulence in mice. Abrogation of the phagocyte respiratory burst oxidase during experimental infection with zwf mutant Salmonella causes a prompt restoration of virulence, while inhibition of inducible nitric oxide synthase...
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