Article
The role of hepatocyte nuclear factor-3 alpha (Forkhead Box A1) and androgen receptor in transcriptional regulation of prostatic genes.
Molecular endocrinology (Baltimore, Md.) - 1 Aug 2003
Gao Nan, Zhang Jianfeng, Rao Mira A, Case Thomas C, Mirosevich Janni, Wang Yongqing, Jin Renjie, Gupta Aparna, Rennie Paul S, Matusik Robert J
Abstract excerpt
Androgens and mesenchymal factors are essential extracellular signals for the development as well as the functional activity of the prostate epithelium. Little is known of the intraepithelial determinants that are involved in prostatic differentiation. Here we found that hepatocyte nuclear factor-3 alpha (HNF-3 alpha), an endoderm developmental factor, is essential for androgen receptor (AR)-mediated prostatic...
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