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Article

High exogenous homocysteine modifies eye development in early chick embryos

1 Jan 2003

Abstract excerpt

BACKGROUND: Homocysteine is a nonessential aminoacid whose increase is related to the appearance of neural tube defects in humans. In chick embryos, high levels of homocysteine produce neural tube defects and alteration of neural crest cell migration. METHODS: In our study, 8 microl of L-homocysteine thiolatone (20 micromol) was added to chick embryos of Stages 3-8/10 (Hamburger and Hamilton, 1951), (1238 hr of...

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PMID: 12749382
DOI: 10.1002/bdra.10014

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