Article
Molecular grading of urothelial cell carcinoma with fibroblast growth factor receptor 3 and MIB-1 is superior to pathologic grade for the prediction of clinical outcome.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 May 2003
van Rhijn Bas W G, Vis André N, van der Kwast Theo H, Kirkels Wim J, Radvanyi François, Ooms Engelbert C M, Chopin Dominique K, Boevé Egbert R, Jöbsis Adriaan C, Zwarthoff Ellen C
Abstract excerpt
PURPOSE: Fibroblast growth factor receptor 3 (FGFR3) mutations were recently found at a high frequency in well-differentiated urothelial cell carcinoma (UCC). We investigated the relationship between FGFR3 status and three molecular markers (MIB-1, P53, and P27kip1) associated with worse prognosis and determined the reproducibility of pathologic grade and molecular variables. PATIENTS AND METHODS: In this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.