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Article

The heritability of bipolar affective disorder and the genetic relationship to unipolar depression.

Archives of general psychiatry - 1 May 2003

McGuffin Peter, Rijsdijk Fruhling, Andrew Martin, Sham Pak, Katz Randy, Cardno Alastair

Abstract excerpt

BACKGROUND: Twin studies of bipolar affective disorder (BPD) have either been small or have not used explicit diagnostic criteria. There has been little use of genetic model fitting and no analyses to explore the etiological overlap with unipolar depression (UPD). METHODS: Sixty-seven twin pairs, 30 monozygotic and 37 dizygotic, in which the proband had BPD were ascertained, and lifetime diagnoses were made using...

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Identifiers

PMID: 12742871
DOI: 10.1001/archpsyc.60.5.497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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