Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oligogenic segregation analysis of hereditary prostate cancer pedigrees: evidence for multiple loci affecting age at onset.

International journal of cancer - 10 Jul 2003

Conlon Erin M, Goode Ellen L, Gibbs Mark, Stanford Janet L, Badzioch Michael, Janer Marta, Kolb Suzanne, Hood Lee, Ostrander Elain A, Jarvik Gail P, Wijsman Ellen M

Abstract excerpt

Previous studies have suggested strong evidence for a hereditary component to prostate cancer (PC) susceptibility. Here, we analyze 3,796 individuals in 263 PC families recruited as part of the ongoing Prostate Cancer Genetic Research Study (PROGRESS). We use Markov chain Monte Carlo (MCMC) oligogenic segregation analysis to estimate the number of quantitative trait loci (QTLs) and their contribution to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to Bayes Theorem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Neoplasms

Share to Chromosome Segregation

Share to Markov Chains

Share to Neoplastic Syndromes, Hereditary

Share to Prostate-Specific Antigen

Share to Prostatic Neoplasms

Source

Identifiers

PMID: 12740911
DOI: 10.1002/ijc.11128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oligogenic segregation analysis of hereditary prostate cancer pedigrees: evidence for multiple loci affecting age at onset.PMID 12740911Read ↗

Genomic scan of 254 hereditary prostate cancer families.Semantic proximity Read ↗

An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study.Semantic proximity Read ↗

Mendelian inheritance of familial prostate cancer.Semantic proximity Read ↗

Genome-wide linkage analysis for aggressive prostate cancer in Utah high-risk pedigrees.Semantic proximity Read ↗

Prostate cancer susceptibility locus HPC1 in Utah high-risk pedigrees.Semantic proximity Read ↗

Linkage analysis of chromosome 1q markers in 136 prostate cancer families. The Cancer Research Campaign/British Prostate Group U.K. Familial Prostate Cancer Study Collaborators.Semantic proximity Read ↗

Multivariate logistic regression for familial aggregation in age at disease onset.Semantic proximity Read ↗

Segregation analyses of 1,476 population-based Australian families affected by prostate cancer.Semantic proximity Read ↗

Linkage analyses at the chromosome 1 loci 1q24-25 (HPC1), 1q42.2-43 (PCAP), and 1p36 (CAPB) in families with hereditary prostate cancer.Semantic proximity Read ↗

Segregation analysis of prostate cancer in France: evidence for autosomal dominant inheritance and residual brother-brother dependence.Semantic proximity Read ↗

A polymorphism in the CDKN1B gene is associated with increased risk of hereditary prostate cancer.Semantic proximity Read ↗

Bayesian oligogenic analysis of quantitative and qualitative traits in general pedigrees.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.