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Article

Asn441 plays a key role in folding and function of the Na+/I- symporter (NIS).

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2013

Li Wenjing, Nicola Juan Pablo, Amzel L Mario, Carrasco Nancy

Abstract excerpt

The Na(+)/I(-) symporter (NIS) is a plasma membrane glycoprotein that mediates active I(-) transport in the thyroid, the first step in the biosynthesis of the iodine-containing thyroid hormones T3 and T4. Several NIS mutants have been identified as a cause of congenital I(-) transport defect (ITD...

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Identifiers

PMID: 23650190
DOI: 10.1096/fj.13-229138
PMCID: PMC3714583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23650190-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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