Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of functionally important sites in the first intracellular loop of the NaPi-IIa cotransporter.

American journal of physiology. Renal physiology - 1 Apr 2002

Köhler Katja, Forster Ian C, Stange Gerti, Biber Jürg, Murer Heini

Abstract excerpt

Intrasequence comparison of the type IIa Na(+)-P(i) cotransport protein revealed two regions with high similarity in the first intracellular (ICL-1) and third extracellular (ECL-3) loops. Because the ECL-3 loop contains functionally important sites that have been identified by cysteine scanning, we applied this method to corresponding sites in the ICL-1 loop. The accessibility of novel cysteines by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Cysteine
Share to Immunoblotting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Indicators and Reagents

Share to Phosphates

Share to Sodium

Share to Symporters

Share to Xenopus laevis

Source

Identifiers

PMID: 11880330
DOI: 10.1152/ajprenal.00282.2001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of functionally important sites in the first intracellular loop of the NaPi-IIa cotransporter.PMID 11880330Read ↗

Essential cysteine residues of the type IIa Na+/Pi cotransporter.Semantic proximity Read ↗

Conferring electrogenicity to the electroneutral phosphate cotransporter NaPi-IIc (SLC34A3) reveals an internal cation release step.Semantic proximity Read ↗

Asn441 plays a key role in folding and function of the Na+/I- symporter (NIS).Semantic proximity Read ↗

The fourth transmembrane domain of the Helicobacter pylori Na+/H+ antiporter NhaA faces a water-filled channel required for ion transport.Semantic proximity Read ↗

The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways.Semantic proximity Read ↗

Structure and function of ClC chloride channels.Semantic proximity Read ↗

Identification of residues that control Li+ versus Na+ dependent Ca2+ exchange at the transport site of the mitochondrial NCLX.Semantic proximity Read ↗

Functional characterization of two naturally occurring mutations in the human sodium-phosphate cotransporter type IIa.Semantic proximity Read ↗

Structural and functional analysis of critical amino acids in TMVI of the NHE1 isoform of the Na+/H+ exchanger.Semantic proximity Read ↗

Altered ionic selectivity of the sodium channel revealed by cysteine mutations within the pore.Semantic proximity Read ↗

Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface.Semantic proximity Read ↗

Investigating the surface expression of the renal type IIa Na+/Pi-cotransporter in Xenopus laevis oocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.