Article
Genetic rescue of chondrodysplasia and the perinatal lethal effect of cartilage link protein deficiency.
The Journal of biological chemistry - 3 Oct 2003
Czipri Mátyás, Otto Jeffrey M, Cs-Szabó Gabriella, Kamath Rajesh V, Vermes Csaba, Firneisz Gábor, Kolman Kevin J, Watanabe Hideto, Li Yefu, Roughley Peter J, Yamada Yoshihiko, Olsen Björn R, Glant Tibor T
Abstract excerpt
The targeted disruption of cartilage link protein gene (Crtl1) in homozygous mice resulted in a severe chondrodysplasia and perinatal lethality. This raised the question of whether the abnormalities seen in Crtl1 null mice are all caused by the absence of link protein in cartilage or whether the deficiency of the protein in other tissues and organs contributed to the phenotype. To address this question we have...
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