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Article

Contribution of presenilin/gamma-secretase to calsenilin-mediated apoptosis.

Biochemical and biophysical research communications - 23 May 2003

Jo Dong-Gyu, Chang Jae-Woong, Hong Hyun-Seok, Mook-Jung Inhee, Jung Yong-Keun

Abstract excerpt

Mutant presenilins cause early-onset of familial Alzheimer's disease and render cells vulnerable to apoptosis. Calsenilin/DREAM/KChIP3 is a multifunctional calcium-binding protein that interacts with presenilin and mediates calcium-mediated apoptosis. In the present study, we report that the calsenilin-mediated apoptosis is regulated by presenilin. The expression of calsenilin was highly up-regulated in neuronal...

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Identifiers

PMID: 12732196
DOI: 10.1016/s0006-291x(03)00688-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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