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Article

[Autoimmune lymphoproliferative syndrome: molecular diagnosis in two families].

Medicina clinica - 3 May 2003

Cambronero Rosario, Cámara Carmen, López-Granados Eduardo, Ferreira Antonio, Fontán Gumersindo, García Rodríguez M Cruz

Abstract excerpt

BACKGROUND AND OBJECTIVE: The autoimmune lymphoproliferative syndrome (ALPS) is a disorder caused by a defect in lymphocytes' apoptosis and characterized by non malignant lymphoproliferation, autoimmune features and increased TCR alpha + CD4CD8 cells. Most patients have a mutation in the TNFRSF6 gene, which encodes the Fas protein. Our aim was to identify mutations in this gene in two families with possible ALPS...

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Source

Identifiers

PMID: 12732128
DOI: 10.1016/s0025-7753(03)73790-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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